Recent Publications With DCAN Authors

Despite decades of neuroimaging research, how white matter develops along the length of major tracts in humans remains unknown. Here, we identify fundamental patterns of white matter maturation by examining developmental variation along major, long-range cortico-cortical tracts in youth ages 5-23 years using diffusion MRI from three large-scale, cross-sectional datasets (total N = 2,710). Across […]

CONCLUSION: Structural covariance of early visual cortex was robustly associated with PTSD symptoms across an international, heterogeneous sample of trauma survivors. Future studies should aim to identify specific mechanisms that underlie structural alterations in the visual cortex to better understand posttrauma psychopathology.

No abstract

CONCLUSIONS: Glutamate dehydrogenase appears to be a clinically useful predictor of liver disease in avians as in mammals. However, this liver biomarker is able to rule in liver disease, although it cannot definitively rule it out.

The human cerebral cortex contains groups of areas that support sensory, motor, cognitive, and affective functions, often categorized into functional networks. These networks show stronger internal and weaker external functional connectivity (FC), with FC profiles more similar within the same network. Previous studies have shown these networks develop from nascent forms before birth to their […]

The precise network topology of functional brain systems is highly specific to individuals and undergoes dramatic changes during critical periods of development. Large amounts of high-quality resting state data are required to investigate these individual differences, but are difficult to obtain in early infancy. Using the template matching method, we generated a set of infant […]

CONCLUSIONS: The motion-ordering and bagging methods are two feasible approaches that can enhance sample representation for testing brain-behavior associations and result in reproducible effect sizes in diverse populations.

Cutaneous squamous cell carcinoma is one of the most common cancers in humans and kills as many people annually as melanoma. The understanding of the transcriptional changes with respect to high-risk clinical/histopathologic features and outcome is poor. In this study, we examine stage-matched, outcome-differentiated cutaneous squamous cell carcinoma using whole-exome and transcriptome sequencing. Exome analysis […]

Developmental trajectories during the transition from adolescence to adulthood contribute to the establishment of stable, adult forms of operation. Understanding the neural mechanisms underlying this transition is crucial for identifying variability in normal development and the onset of psychiatric disorders, which typically emerge during this time. Habitual behaviors can serve as a model for understanding […]

No abstract

Brain-wide association studies (BWAS) are a fundamental tool in discovering brain-behaviour associations^(1,2). Several recent studies have shown that thousands of study participants are required for good replicability of BWAS^(1-3). Here we performed analyses and meta-analyses of a robust effect size index using 63 longitudinal and cross-sectional MRI studies from the Lifespan Brain Chart Consortium⁴ (77,695 […]

No abstract

Reproducibility of neuroimaging research on infant brain development remains limited due to highly variable protocols and processing approaches. Progress towards reproducible pipelines is limited by a lack of benchmarks such as gold standard brain segmentations. Addressing this core limitation, we constructed the Baby Open Brains (BOBs) Repository, an open source resource comprising manually curated and […]

Extensive investigations spanning multiple levels of inquiry, from genetic to behavioural studies, have sought to unravel the mechanistic foundations of attention-deficit hyperactivity disorder (ADHD), with the aspiration of developing efficacious treatments for this condition. Despite these efforts, the pathogenesis of ADHD remains elusive. In this Review, we reflect on what has been learned about ADHD […]

CONCLUSIONS AND RELEVANCE: Polygenic risk for transdiagnostic adulthood psychopathology is associated with both p-factor and heritable PFN topography during early adolescence. These results advance our understanding of the developmental drivers of psychopathology.